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dc.contributor.advisorBerçin, Erdoğan
dc.contributor.authorKaranci, Yeliz
dc.date.accessioned2020-12-29T08:11:12Z
dc.date.available2020-12-29T08:11:12Z
dc.date.submitted2005
dc.date.issued2018-08-06
dc.identifier.urihttps://acikbilim.yok.gov.tr/handle/20.500.12812/356734
dc.description.abstract-72- VI.ÖZET Bu çalışmada dimetil benzilidenmalonatlar ile L-sisteinin reaksiyonu incelenmiştir. Dimetil benzilidenmalonat türevleri, dimetil malonatlarla çeşitli benzaldehit türevlerinin kondenzasyonu ile elde edilmiştir. Sentezlenen bileşiklere L- sisteinin katımı ile S(2,2-Dimetoksikarbonil-l-feniletil)-L-sistein türevlerine geçilmiştir. Elde edilen altı adet türevin sentezinde Kim ve Chao'nun kullandıkları yöntemden yararlanılmıştır. Oluşan türevlerin yapılarının aydınlatılmasında; elementel analiz, IR, 1H-NMR, LC/MS, 13C-NMR, HETCOR, DEPT, NOESY, COSY ve HMBC spektroskopik analiz yöntemleri kullanılmıştır.-73- Tablo 1: Sentezi enen Dimetil benzilidenmalonat Türevleri COOMe COOMe Tablo2: Sentezlenen S(2,2-Dimetoksikarbonil-l-feniletil)-L-sistein Türevleri COOH H3COOC COOCH3
dc.description.abstract-74- VII. SUMMARY In this study, the reaction of dimethyl benzylidenemalonates with L-cysteine was invastigated. The derivatives of dimethyl benzylidenemalonates were prepared by the condensation of dimethyl malonate and appropriate benzaldehyde derivatives. The reaction of dimethyl benzylidenemalonates with L-cysteine resulted the addition product. The synthetic methodology used synthesis of six S(2,2-dimethoxycarbonyl-l- substituted phenylethyl)-L-cysteine derivatives was reported in the study of Kim and Chao et al75.-75- The stucture elucidation of the synthesized compounds were done by elementary analise, IR, 1H-NMR, LC/MS, 13C-NMR, HETCOR, DEPT, NOESY, COSY and HMBC. Table 1: Dimethyl benzylidenemalonates Derivatives R,COOMe COOMe-76- Table2: S(2,2-Dimethoxycarbonyl-l -phenylethyl)-L-cysteine Derivatives COOH H3COOC COOCH3en_US
dc.languageTurkish
dc.language.isotr
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.rightsAttribution 4.0 United Statestr_TR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEczacılık ve Farmakolojitr_TR
dc.subjectPharmacy and Pharmacologyen_US
dc.titleL-sistein ve dimetil benzilidenmalonat türevlerinin verdiği reaksiyonlrın incelenmesi
dc.title.alternativeInvestigation of the reaction of L-cysteine with dimethyl benzylidenemalonate derivatives
dc.typemasterThesis
dc.date.updated2018-08-06
dc.contributor.departmentFarmasötik Kimya Anabilim Dalı
dc.identifier.yokid184513
dc.publisher.instituteSağlık Bilimleri Enstitüsü
dc.publisher.universityGAZİ ÜNİVERSİTESİ
dc.identifier.thesisid164424
dc.description.pages92
dc.publisher.disciplineDiğer


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