1-[5-kloro-3H-benzoksazolin-2-on-3-il]asetil-2-(2/4-sübstitüe benzal) hidrazon türevlerinin sentezi, yapı aydınlatması ve biyolojik aktiviteleri üzerinde çalışmalar
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Abstract
91 Table-2. The yields and the melting points of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2-(2/4-substituted benzal) hydrazone derivatives. CH2-C- NH-N=CH-^ The structure elucidation of the fourteen title compounds were done by means of their spectral analyses.92 The biological activity for anticonvulsant effectiveness were accomplished and results are given in Table 1. Table-1. Anticonvulsant activity results of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2- (2/4-substituted benzal)hydrazone derivatives. P<0.05, Dose: 100mg/kg intraperitonale As shown from Table-1, compounds 7 (2-OMe), 10 (2-Me), 11 (4-Me), 16 (4-Me) and 17 (4-NMe2) showed considerable anticonvulsant activity.91 Table-2. The yields and the melting points of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2-(2/4-substituted benzal) hydrazone derivatives. CH2-C- NH-N=CH-^ The structure elucidation of the fourteen title compounds were done by means of their spectral analyses.92 The biological activity for anticonvulsant effectiveness were accomplished and results are given in Table 1. Table-1. Anticonvulsant activity results of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2- (2/4-substituted benzal)hydrazone derivatives. P<0.05, Dose: 100mg/kg intraperitonale As shown from Table-1, compounds 7 (2-OMe), 10 (2-Me), 11 (4-Me), 16 (4-Me) and 17 (4-NMe2) showed considerable anticonvulsant activity. 91 Table-2. The yields and the melting points of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2-(2/4-substituted benzal) hydrazone derivatives. CH2-C- NH-N=CH-^ The structure elucidation of the fourteen title compounds were done by means of their spectral analyses.92 The biological activity for anticonvulsant effectiveness were accomplished and results are given in Table 1. Table-1. Anticonvulsant activity results of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2- (2/4-substituted benzal)hydrazone derivatives. P<0.05, Dose: 100mg/kg intraperitonale As shown from Table-1, compounds 7 (2-OMe), 10 (2-Me), 11 (4-Me), 16 (4-Me) and 17 (4-NMe2) showed considerable anticonvulsant activity.91 Table-2. The yields and the melting points of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2-(2/4-substituted benzal) hydrazone derivatives. CH2-C- NH-N=CH-^ The structure elucidation of the fourteen title compounds were done by means of their spectral analyses.92 The biological activity for anticonvulsant effectiveness were accomplished and results are given in Table 1. Table-1. Anticonvulsant activity results of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2- (2/4-substituted benzal)hydrazone derivatives. P<0.05, Dose: 100mg/kg intraperitonale As shown from Table-1, compounds 7 (2-OMe), 10 (2-Me), 11 (4-Me), 16 (4-Me) and 17 (4-NMe2) showed considerable anticonvulsant activity.
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