Üçüncü kuşak sefalosporin ve kinolon türevi kemoterapötiklerin immun yanıt üzerine etkilerinin araştırılması

Abstract

63 SUMMARY Recently it is suggested that chemotherapeutics have not only antimic robial activities, but also they are effective on the functions of the immuno- component cells as well. în this research the effects of 6 antimicrobial agents, mainly third generation cephalosporines and Quinolon derivatives, and a known immunosuppressive drug were studied at the humoral and cellular base. These were Ceftriaxone, Ceftazidime and Cefotaxime (third generation Cephalosporine), Ciprofloxacin (third generation Quinolon), Fluconazole (antimycotic), Amikacin (antimicrobial) and Cyclophosphamide (immuno- suppressive). The effects of these drugs on immune response at the humoral base were studied by means of antibody levels and by examining the PPD reac tions after BCG vaccinating of PPD negative rabbits at the cellular base. The in-vivo antibody results of these agents againts Salmonella typhi H and O antigents are summerized in table 2-9, the cellular immune respon se results are described in table 10 and the graphics are shown in figures 1-14 and 15-21 respectively. Two different control groups were used in order to make a certaine re ference. The humoral response was suppressed after a short stimulation fase by Ceftriaxone. This suppression is not as high as that get by Cyclophosphami de, however, it is meaningful yet. So it seems to be a untitled delayed supp ression on the immune response at the humoral base, wherease it is at a high level at the cellular base. Applying Ceftazidim, the humoral response was not affected, where the cellular response was suppressed as high as that of Ceftriaxone. în the case of Ciprofloxacin, the humoral response was suppressed ra-64 pidly after a short period of stimulation. The cellular response, however, is directly stimulated. Cephotaxime suppressed particularly both the humoral and the cellu- lar responses. The humoral response was not affected by Fluconazol, in spite of the cellular response which was lowly suppressed in long term. The last agent was Amikacin. The humoral response was suppressed in long term. Delayed hypersensitivity of cellular response was fifthy percently suppressed. Although it is hard to state the immune response totally, either humo ral or cellular, because the matter is not known completely and the data are not satisfying, this is a fact that any drug which is highly taken to the organi- sim, will effect the immune system. So it is important not to use any anti microbial agent or other therapeutics by chance.

63 SUMMARY Recently it is suggested that chemotherapeutics have not only antimic robial activities, but also they are effective on the functions of the immuno- component cells as well. în this research the effects of 6 antimicrobial agents, mainly third generation cephalosporines and Quinolon derivatives, and a known immunosuppressive drug were studied at the humoral and cellular base. These were Ceftriaxone, Ceftazidime and Cefotaxime (third generation Cephalosporine), Ciprofloxacin (third generation Quinolon), Fluconazole (antimycotic), Amikacin (antimicrobial) and Cyclophosphamide (immuno- suppressive). The effects of these drugs on immune response at the humoral base were studied by means of antibody levels and by examining the PPD reac tions after BCG vaccinating of PPD negative rabbits at the cellular base. The in-vivo antibody results of these agents againts Salmonella typhi H and O antigents are summerized in table 2-9, the cellular immune respon se results are described in table 10 and the graphics are shown in figures 1-14 and 15-21 respectively. Two different control groups were used in order to make a certaine re ference. The humoral response was suppressed after a short stimulation fase by Ceftriaxone. This suppression is not as high as that get by Cyclophosphami de, however, it is meaningful yet. So it seems to be a untitled delayed supp ression on the immune response at the humoral base, wherease it is at a high level at the cellular base. Applying Ceftazidim, the humoral response was not affected, where the cellular response was suppressed as high as that of Ceftriaxone. în the case of Ciprofloxacin, the humoral response was suppressed ra-64 pidly after a short period of stimulation. The cellular response, however, is directly stimulated. Cephotaxime suppressed particularly both the humoral and the cellu- lar responses. The humoral response was not affected by Fluconazol, in spite of the cellular response which was lowly suppressed in long term. The last agent was Amikacin. The humoral response was suppressed in long term. Delayed hypersensitivity of cellular response was fifthy percently suppressed. Although it is hard to state the immune response totally, either humo ral or cellular, because the matter is not known completely and the data are not satisfying, this is a fact that any drug which is highly taken to the organi- sim, will effect the immune system. So it is important not to use any anti microbial agent or other therapeutics by chance.