Tekrarlayan spontan düşüklerde fetal, maternal ve paternal sitogenetik incelenmeler ve klinik korelasyonları

Abstract

In this issue, we aimed to determine the role of cytogenetic factors in our population in recurrent abortions and to improve the cytogenetic analysis methods of fetal tissue samples. In our study results of the cytogenetic analysis, made from the peripheral blood samples of parents and other family members, if needed after the consideration of the pedigree features, in 107 families having two or more abortion (recurrent abortion) histories, and from the chorionic tissues of 20 spontaneous abortion materials, are presented. In 3 of our families, prenatal cytogenetic analysis is made. Thus, total number of materials we studied on is 28 1. The rate of chromosomal changes in 127 family, cytogenetically analyzed from peripheral blood samples, is found to be 7.8 % (10/127). Chromosomal analysis of abortion materials revealed an anomaly rate of 38.8 %. 93It is observed that combined practicing of direct and long term culture methods carried on chorionic tissues of abortion material has a positive effect on the results. Consanguinity rate of the parents showed no deviation from the normal population rate (17.3). The mean age of maternal reproductivity is observed to be in normal population range (27.5). Among the abortion materials, the mean maternal age of the cases found to have trisomy (37.6) is significantly above the normal population values. Combining the data of our study, cytogenetic studies carried on the families with recurrent abortions present in their reproductive history, are thought to have a great impact to find the etiologies of related abortions and to determine the way to follow on the future pregnancies. Our study provided us to use new methods related to cytogenetic analysis of fetal tissues in our laboratory.