Aminobenzoik asitlerin 2-karboksibenzaldehit türevleri ve onların komplekslerinin sentezi, yapısal ve biyolojik özelliklerinin belirlenmesi

Abstract

Bu çalışmada üç adet (I, II, III) yeni ligand ve dört adet yeni (IV, V, VI, VII) kompleks ilk kez sentezlenmiştir. 2-(3-okso-1,3-dihidroizobenzofuran-1-il)aminobenzoik asit (C15H11NO4)I3-(3-okso-1,3-dihidroizobenzofuran-1-il)aminobenzoik asit (C15H11NO4)II4-(3-okso-1,3-dihidroizobenzofuran-1-il)aminobenzoik asit (C15H11NO4)IIItetramethanolbis(3-(3-okso-1,3-dihidroizobenzofuran-1-il)aminobenzoato)çinko(II) (C34H36ZnN2O12)IVtetramethanolbis(3-(3-okso-1,3-dihidroizobenzofuran-1-il)aminobenzoato)kobalt(II) (C34H36CoN2O12)Vtetramethanolbis(4-(3-okso-1,3-dihidroizobenzofuran-1-il)aminobenzoato)kobalt(II) (C34H36CoN2O12)VItetramethanolbis(4-(3-okso-1,3-dihidroizobenzofuran-1-il)aminobenzoato)nikel(II)(C34H36N2NiO12) VIILigandların ve komplekslerin yapılarını aydınlatmak için elementel analiz, 1H-NMR, 1C-NMR, FT-IR spektroskopisi, UV-Vis, ve X-ray yöntemleri kullanılmıştır. Ayrıca ligandların ve komplekslerin antibakteriyel aktiviteleri agar kuyucuk difüzyon yöntemiyle incelenmiştir.

In this study, three new ligands (I, II, III) and four new complexes were first synthesized (IV, V, VI, VII) for the first time. 2-(3-oxo-1,3-dihydroisobenzofuran-1-yl)aminobenzoic acid (C15H11NO4)I3-(3-oxo-1,3-dihydroisobenzofuran-1-yl)aminobenzoic acid (C15H11NO4)II4-(3-oxo-1,3-dihydroisobenzofuran-1-yl)aminobenzoic acid (C15H11NO4)IIItetramethanolbis(3-(3-oxo-1,3-dihydroisobenzofuran-1-yl)aminobenzoato)zinc(II)(C34H36ZnN2O12)IVtetramethanolbis(3-(3-oxo-1,3-dihydroisobenzofuran-1-yl)aminobenzoato)cobalt(II)(C34H36CoN2O12)Vtetramethanolbis(4-(3-oxo-1,3-dihydroisobenzofuran-1-yl)aminobenzoato)cobalt(II)(C34H36CoN2O12)VItetramethanolbis(4-(3-oxo-1,3-dihydroisobenzofuran-1-yl)aminobenzoato)nickel(II)(C34H36N2NiO12)VIIElemental analysis, 1H-NMR, 1C-NMR, UV-Vis FT-IR spectroscopy and X-ray methods were used to elucidate the structures of ligands and complexes. In addition, antibacterial activities of complexes and ligands were investigated by agar well diffusion method.