Abstract
Özdemir H. Effect Of Phase I Periodontal Therapy On Gingival Crevicular Fluid Myeloperoxidase Levels Of Chronic Periodontitis Patients With And Without Type II Diabetes Mellitus. Cumhuriyet University Graduate School of Health Sciences, Ph.D. Thesis in Periodontology, Sivas,This study aimed to evaluate the effect of Phase I periodontal therapy on gingival crevicular fluid myeloperoxidase levels of Type II diabetes mellitus and systemically healthy chronic periodontitis patients and analyzed the correlation between clinical parameters and myeloperoxidase levels.Study population (34 female, 31 male) formed three groups: 1) Chronic periodontitis patients with Type II Diabetes mellitus, 2) Systemically healthy chronic periodontitis patients, 3) Healthy subjects. Plaque index, Gingival index, Bleeding time index, probing pocket depth, and attachment level measurements were done to analyze periodontal status of the subjects. Myeloperoxidase activity levels were measured from the gingival crevicular fluid samples collected from the subjects in the morning between 8:30-10:00 a.m. All measurements and sample collections repeated in 1,5 and 3 months after.Analysis of variance and Tukey tests were used in statistical analyzis.Results showed a statistical improvement in clinical parameters of periodontitis patients (p<0,05). Clinical parameters did not change in control group (p>0,05). Also, while a significant decrease in the gingival crevicular fluid myeloperoxidase levels in periodontitis groups were observed (p<0,05), no significant difference was seen in control group (p>0,05).As a result, we can suggest a destructive role for myeloperioxidase as it was present both in the gingival crevicular fluid of systemically healthy and Type II diabetic chronic patient groups. Also we think that, gingival crevicular myeloperoxidase may help us to better understand the diminished host response in these patient groups
