Lokalize jüvenil periodontitisli hastalarda iki farklı antibiyotik tedavi yönteminin klinik ve mikrobiyolojik açıdan incelenmesi

Abstract

45 SUMMARY In this study 30 patients diagnosed LJP have been divided into two groups (15 patients each) and different antibiotic regimens together with conventional periodontal therapy have been applied. Follow up results in a three month's period have been evaluated both clinically and microbiologically. Patients in the first group have received doxycycline for ten days (100 mg daily). Second group have received metronidazole plus amoxycillin (250 mg + 375 mg TID). Clinical indicators together with plaque samples from periodontal pockets have been evaluated beginning of the treatment, tenth day, first, second and third months. Probing pocket depths, plaque index (P1I), gingival index (GI) and attachment loss have been recorded. Subgingival plaque samples have been evaluated for the presence and ratio of Aa in total counts. Second group that have used combined antibiotics have shown a statistically significant decrease in P1I and GI first months compared third month results (p<0.05).When indices have been evaluated in the same group, values have shown a significant decrease in all study periods. Probable pocket depths and attachment levels have shown no significant difference between two groups. However, significant decrease have been observed in probable pocket depths, in each group, in all study periods. Attachment levels have shown a gain starting from tenth days in both groups. In microbiological evaluation patients of the first group have shown no growth of Aa colonies on culture in the following evaluation periods. Only two patients have shown small amounts of Aa growths in the second evaluation but they have disappeared in the following periods. In the light of above knowledge, two different antibiotic's regimes together with conventional periodontal therapy has not been shown superior to each other46 on a microbiological basis but combined antibiotic treatment regimes have been found more effective on Gl and PİL

45 SUMMARY In this study 30 patients diagnosed LJP have been divided into two groups (15 patients each) and different antibiotic regimens together with conventional periodontal therapy have been applied. Follow up results in a three month's period have been evaluated both clinically and microbiologically. Patients in the first group have received doxycycline for ten days (100 mg daily). Second group have received metronidazole plus amoxycillin (250 mg + 375 mg TID). Clinical indicators together with plaque samples from periodontal pockets have been evaluated beginning of the treatment, tenth day, first, second and third months. Probing pocket depths, plaque index (P1I), gingival index (GI) and attachment loss have been recorded. Subgingival plaque samples have been evaluated for the presence and ratio of Aa in total counts. Second group that have used combined antibiotics have shown a statistically significant decrease in P1I and GI first months compared third month results (p<0.05).When indices have been evaluated in the same group, values have shown a significant decrease in all study periods. Probable pocket depths and attachment levels have shown no significant difference between two groups. However, significant decrease have been observed in probable pocket depths, in each group, in all study periods. Attachment levels have shown a gain starting from tenth days in both groups. In microbiological evaluation patients of the first group have shown no growth of Aa colonies on culture in the following evaluation periods. Only two patients have shown small amounts of Aa growths in the second evaluation but they have disappeared in the following periods. In the light of above knowledge, two different antibiotic's regimes together with conventional periodontal therapy has not been shown superior to each other46 on a microbiological basis but combined antibiotic treatment regimes have been found more effective on Gl and PİL