Köpeklerde karbonhidrattan zengin diet ve ethanolün safra kesesi taşı ve HDL kolesterolü üzerine etkileri

Abstract

90 SUMMARY This study was performed in the Surgical Research Laboratory of Erciyes University Medical School, between September 1990 - November 1990. Three groups of dogs, each group is composed of five dogs, were included in the study. The first group was given a carbohydrate diet and the second group was given a carbohydrate diet added ethanol account % 35 of total calorie and the third group was given a control diet for during 12 weeks. Blood samples were taken before and after the study. Ultrasonography was performed after the study and laparatomy was done. After91 chalesystectomy, the materials were examined for stone, sludge and crystals. Liver biopsies were taken and the biopsy material and gallbladder were examined h istopatolog ica 1 ly. In the first group, gallstones in two dogs, bile sludge in three dogs, and calcium bilirubinate crystals in all were observed- In the second group; no gallstone was observed, but a little bile sludge in a dog and there was some calcium bilirubinate, crystalloid in another dog. The levels of the total plasma cholesterol, the plasma calcium and the bile cholesterol, the bile calcium and the bile salts in the first group were, all found higher than the second and the control groups values (P < O. 05 ). The diet with ethanol reduced the effect of lithogenic diet and decreased all of these values. There was no significant differences among the total bile b i 1 i rub i ne values of the three groups. In addition, using the diet with carbohydrate, decreased the HDL cholesterol values and increased the plasma cholesterol values. However ethanol increased HDL cholesterol values and decreased plasma cholesterol values by increasing LpL ac t i v i ty.

90 SUMMARY This study was performed in the Surgical Research Laboratory of Erciyes University Medical School, between September 1990 - November 1990. Three groups of dogs, each group is composed of five dogs, were included in the study. The first group was given a carbohydrate diet and the second group was given a carbohydrate diet added ethanol account % 35 of total calorie and the third group was given a control diet for during 12 weeks. Blood samples were taken before and after the study. Ultrasonography was performed after the study and laparatomy was done. After91 chalesystectomy, the materials were examined for stone, sludge and crystals. Liver biopsies were taken and the biopsy material and gallbladder were examined h istopatolog ica 1 ly. In the first group, gallstones in two dogs, bile sludge in three dogs, and calcium bilirubinate crystals in all were observed- In the second group; no gallstone was observed, but a little bile sludge in a dog and there was some calcium bilirubinate, crystalloid in another dog. The levels of the total plasma cholesterol, the plasma calcium and the bile cholesterol, the bile calcium and the bile salts in the first group were, all found higher than the second and the control groups values (P < O. 05 ). The diet with ethanol reduced the effect of lithogenic diet and decreased all of these values. There was no significant differences among the total bile b i 1 i rub i ne values of the three groups. In addition, using the diet with carbohydrate, decreased the HDL cholesterol values and increased the plasma cholesterol values. However ethanol increased HDL cholesterol values and decreased plasma cholesterol values by increasing LpL ac t i v i ty.