Yaşa bağlı makula dejenerasyonunda koroidal neovaskülarizasyonun verteporfinle fotodinamik tedavisi

Abstract

ÖZET<$ù$%$ö/,0$.8/$'(-(1(5$6<2181'$.252ø'$/1(29$6.h/$5ø=$6<21819(57(325)ø1/()272'ø1$0ø.7('$9ø6ø'U0HOWHPù25$%$785<DúD ED÷Oà PDNXOD GHMHQHUDV/RQXQGD NRURLGDO QHRYDVNÂODUL]DV/RQXQ.19YHUWHSRUILQOHIRWRGLQDPLNWHGDYLVLQLDUDúWÃUGÃ÷ÃPÃ]EXoDOÃúPDGDKDVWDQÃQJ]ÂQHVWDQGDUW SDUDPHWUHOHUOH IRWRGLQDPLN WHGDYL /DSÃOGà )RWRGLQDPLN WHGDYLQLQ KHPHQVRQUDVÃQGD J]H PJ LQWUDYLWUHDO WULDPVLQRORQ ,97$ HQMHNVL/RQX X/JXODQGÃ.19 EDVNÃQ NODVLN YH JL]OL RODUDN JUXSODQGÃUÃOGà (7'56 /RJ0$5 NDUWà LOH HQ L/LGÂ]HOWLOPLú JUPH NHVNLQOL÷L ELRPLNURVNRSLN PXD/HQH YH IOXRUHVHLQ DQMLRJUDIL )$EDúODQJÃo PXD/HQHVLQGH YH ¶HU D/OÃN DUDODUOD SODQODQDQ NRQWURO PXD/HQHOHULQGH/DSÃOGà 7HNUDU WHGDYL LKWL/DFà )$¶GHNL VÃ]PD GHUHFHVLQH JUH EHOLUOHQGL dDOÃúPD/DGDKLOHGLOHQKDVWDODU.19WLSLQHEDúODQJÃoJUPHNHVNLQOL÷LQHOH]/RQEÂ/ÂNOÂ÷ÂQHYH,97$ HQMHNVL/RQXQD JUH JUXSODQGÃUÃOGà %LULQFLO HWNLQOLOLN VRQXoODUà /RJ0$5 JUPHNHVNLQOL÷LQGHNL GH÷LúLNOLN YH JUPH NHVNLQOL÷LQLQ NRUXQGX÷X KDVWDODUÃQ RUDQÃ/GÃOrtalama takip süresi 10.52 ± D/ RUWDODPD )'7 VD/ÃVà ± ¶GL %DúODQJÃo± 0.404 iken son takipteki ortalama görmeRUWDODPD /RJ0$5 JUPH NHVNLQOL÷L±¶GLNHVNLQOL÷L øVWDWLVWLNVHO RODUDN EDúODQJÃo JUPH NHVNLQOL÷L LOH VRQtakipWHNLJUPHNHVNLQOL÷LDUDVÃQGDIDUN/RNWX*UPHNHVNLQOL÷LQLQNRUXQGX÷XJ]OHULQRUDQÃLVHD/GD D/GDD/GD¶WL.19WLSLQHEDúODQJÃoJUPHNHVNLQOL÷LQHOH]/RQEÂ/ÂNOÂ÷ÂQHYH,97$HQMHNVL/RQXQDJUH/DSÃODQJUXSODUDUDVÃQGDgörmHNHVNLQOL÷LQLQNRUXQPDVÃDoÃVÃQGDQLVWDWLVWLNVHORODUDNIDUN/RNWX+DVWDVD/ÃVÃQÃQD]YHWDNLSVÂUHVLQLQNÃVDROPDVÃQDUD÷PHQYHUWHSRUILQOH/DSÃODQ)'7<%0'¶QDED÷OÃVXEIRYHDO.19WHGDYLVLQGHHWNLOLEXOXQPXúWXU

ABSTRACTPHOTODYNAMIC THERAPY OF CHOROIDAL NEOVASCULARIZATIONIN AGE-RELATED MACULAR DEGENERATION WITH VERTEPORFIN'U0HOWHPù25$%$785In this study, photodynamic therapy of choroidal neovascularization inage-related macular degeneration with verteporfin were investigated. Fifty-five eyes of48 patients with subfoveal CNV secondary to ARMD underwent PDT with verteporfinwith standart parameters. Twenty-four eyes were treated with a 4-mg injection ofintravitreal triamcinolone acetonide(IVT) immediately followed by PDT. CNV subtypeswere classified as predominantly classic CNV and occult CNV. Follow-up visits werescheduled at 3- monthly intervals. Measurement of best-corrected visual acuity usingERTDRS chart, biomicroscopic examination and fluorescein angiography wereperformed at baseline and follow-up visit. Need for PDT retreatment was based onfluorescein angiographic evidence of leakage. The patients were divided into groups bylesion size, initial visual acuity, type of CNV and IVT. The primary efficacy outcomeswere the changes in the LogMAR visual acuities and the proportions of eyes whoseLogMAR visual acuities were maintained. The mean follow-up was 10.52±3,31months. The number of retreatments was 1,6 ±0,75. The mean initial LogMAR visualacuity for all patients was 0.93±0.404. The mean final LogMAR visual acuity for allpatients was 0.95±0.331. There was no statistically significant differences betweenEDVHOLQH DQG ILQDO YÃVXDO DFXLW/ IRU DOO H/HV 7KH SURSRUWLRQV RI H/HV ZKRVH /RgMARvisual acuities were maintained were %89, %82.2, %87.5 at 3, 6 ,12 months. There wasno statistically significant differences between groups which were divided by lesionsize, initial visual acuity, type of CNV and IVT. Although the number of patients in thisstudy was limited and the follow-up period was short, PDT with verteporfin waseffective for maintaining visual acuity in patients with CNV secondary to ARMD.