An investigation of the molecular recognition of sugars by chiral host compounds derivated from cyclodextrin and calix (4) arenes by NMR and molecular model calcultions

Abstract

ÖZET SİKLODEXTRİN VE CALİX (4) ARENLERDEN TÜREYEN KİRAL HOST BİLEŞİKLERİNİN ŞEKERLERLE OLAN MOLEKÜLER TANINMALARININ NMR VE MOLEKÜLER MODEL HESAPLAMALARLA ARAŞTIRILMASI ATAR, Mine Yüksek Lisans Tezi, Kimya Bölümü Tez Yöneticileri: Yrd.Doc.Dr. Yeşim Gül Salman Doç.Dr.Necmettin Pirinççioğlu Eylül 2004, 46 sayfa Kovalent olmayan etkileşimler, enzim ve host katalizli reaksiyonlar ve supramoleküler kompleks oluşumlu kataliz reaksiyonları tartışıldı. Resorsin-calixarene kavitesine katalitik ve kiral gruplar yerleştirilerek yapay, makrosiklik esteraz modeli dizayn edilerek (L)-N- asetil ve (£))-İV-Leucin'nin /j-nitrofenil esterlerinin hidrolizi üzerindeki etkisi araştırıldı. Anahtar sözcükler: Esteraz, enzim katalizli reaksiyon, host bileşikleri

vn ABSTRACT AN INVESTIGATION OF THE MOLECULAR RECOGNITION OF SUGARS BY CHIRAL HOST COMPOUNDS DERTVATED FROM CYCLODEXTRTN AND CALLX(4)ARENES BY NMR AND MOLECULAR MODEL CALCULATIONS ATAR, Mine Master of Science Thesis, Department of Chemistry Supervisors: Assist. Prof. Dr. Yeşim Gül Salman Assoc. Prof. Dr. Necmettin Pirinççioğlu September 2004, 46 pages Non-covalent interactions, kinetics of enzyme-catalysed and the host-mediated reactions, and the catalysis by supramolecular complex formation are disscused. An artificial macrocyclic esterase is designed by introducing catalytic and chiral functional groups onto resorcin-calixarene core and its action is tested on the hydrolysis of />-nitrophenyl esters of (L)-N- acetyl and (D^N-Leucine. Keywords: Esterase, enzyme catalysed reactions, host compounds