Deneysel subaraknoidal kanama sonrası PGE2 ve LTC4 seviyelerine vitamin E ve selenyumun etkileri

Abstract

It was shown in several investigations that after subarachnoidal hemorrhage, the increase in the activity of lipid peroxidation and metabolites of arachidonic acid are the indicators of neuronal damage. In our research we investigated the effects of vitamin E and selenium on the production of PGE2 and LTC4 in the brain after experimental subarachnoidal hemorrhage. The guinea pig's that were used in this research were group in four. Group I - SAH group (0, 30 cc autologous arteryel blood was given to the cisterna magna of the guinea pig), group II - SAH + vitamin E (3 days, 500 mg/kg/day vitamin E was given intraperitonially to guinea pig before SAH), group III - SAH + selenium (3 days, 0,3mg/kg/day selenium was given by nazogastric tube to the guinea pig before SAH), group IV - SAH + selenim + vitamin E (vitamin E and selenium were given 3 days to the guinea pig before SAH as the same dose and way that was stated above).The decrease of the arachidonic asid metabolites by the usage of the vitamin or selenium alone were not statistically significant but when vitamin E selenium were used together, LTC4 was decreased significantly 1/2 hours after SAH. In conclusion, the usage of vitamin E and selenium have a synergic effect on the lipoxygenase pathway which had an important role on the patogenesis of the brain damage after SAH.