Tedavide kullanılan piroksikamın erişkin sıçanların karaciğer, böbrek ve akciğer dokularına olan etkilerinin histolojik olarak incelenmesi

Abstract

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SUMMARYHistological Evalvation of Effects of Piroxicam Used in Treatment on Liver,Kidney and Lung Tissues of Adult RatsNonsteroidal antiinflammatory drugs (NSAID) show their effectvia inhibiting prostaglandin synthesis. Cyclooxygenase (COX) enzyme involves inprostaglandin synthesis pathways. There are two isoenzymes of COX: COX- 1 andCOX- 2. While COX- 2 inhibition is responsible for analgesic and antiinflammatoryeffects of NSAIDs, COX- 1 inhibition accounts for unsolicited side effects. In order toinvestigate the possible dose-dependent effects of drug with piroxicam content onadult liver, kidney and lung tissues, three groups each consisting of five animals havebeen constituted. These were control (Group I), 0.250 mg / kg / day (Group II) and0.500 mg / kg / day (Group III) drug given groups. The planned doses wereadministered intramuscularly for five days. At the end of the study, the liver, kidneyand lung tissues of Group I were normally observed. Granular degeneration andpiknotic nuclei in hepatocytes, sinusoidal congestion and mononuclear cell infiltrationin portal fields were observed in the liver tissues of Group II. However, the level ofthese structural changes was more severe in Group III. Also, it has been observed thatsome hepatocytes have undergone necrotic process. Vascular congestion, perivascularmononuclear cell infiltrations and atropic glomeruls were present in kidney tissues ofGroup II. In addition to these findings, there was hydropic degeneration in proximaland distal tubules of Group III. Interalveolar septum thickening, vascular and alveolarcongestions, parenchymal mononuclear cell infiltrations and smooth muscle fibrilincrement in bronchiole walls were observed in lung tissues of Group II. Thesefindings were more evident in lung tissues of Group III. Also, overall structuralchanges in Group III were more prominent than Group II. The question that whetherthe destructive effects of drug with piroxicam content on rat liver, kidney and lungtissues are related to only piroxicam or other drug contents (ethanol, propylene glycol,etc) warrants further studies in this field.Keywords: Lung, kidney, liver, NSAID, rat