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dc.contributor.advisorÇilingir, Vedat
dc.contributor.authorAtilla, Nuray
dc.date.accessioned2020-12-10T11:12:00Z
dc.date.available2020-12-10T11:12:00Z
dc.date.submitted2018
dc.date.issued2018-12-20
dc.identifier.urihttps://acikbilim.yok.gov.tr/handle/20.500.12812/256812
dc.description.abstractMultipl skleroz, santral sinir sisteminin demiyelinizasyon, aksonal dejenerasyon, inflamasyon, astrogliozis ile karakterize, ön planda beyaz cevherin tutulduğu, korteksi, derin gri cevheri de etkileyebilen kronik nörodejeneratif bir hastalığıdır. Hastalığın üç alt tipi bulunmaktadır. Relapsing remitting multipl skleroz (RRMS) %85 oranla en sık görülen alt tipidir, RRMS hastalarında özürlülüğün ilerlemesiyle ortaya çıkan sekonder progresif multipl skleroz (SPMS) ve en baştan itibaren progresif seyir gösteren primer progresif multipl sklerozdur (PPMS).Çalışmada PPMS ve SPMS hastalarında üst ve alt ekstremite fonksiyonları karşılaştırıldı. Çalışmaya EDSS (Expanded Disability Status Scale) skoru 4.0-8.5 arasında 27'si PPMS, 38'i SPMS olan toplam 65 progresif MS hastası dahil edildi. Kadın/erkek oranı 1,6/1 bulunmuştur.Çalışmada EDSS skoru birbirine yakın olan hastalarda PPMS'de üst ekstremite ince motor becerisinin ve yürüme becerisinin SPMS'e göre istatistiksel olmasa da göreceli olarak daha iyi olduğu bulunmuştur.
dc.description.abstractMultiple sclerosis is a chronic neurodegenerative disease of the central nervous system characterized by demyelination, axonal degeneration, inflammation, astrogliosis. The cortex and deep gray matter can be affected in addition to the white matter. There are three subtypes of the disease. Relapsing remitting multiple sclerosis (RRMS) is the most common subtype with 85%. Other types of the disease are secondary progressive multiple sclerosis (SPMS) with progression of disability in RRMS patients and primary progressive multiple sclerosis (PPMS) progressively progressing from the beginning.In our study, upper and lower extremity functions were compared in PPMS and SPMS patients. A total of 65 progressive MS patients with an EDSS (Expanded Disability Status Scale) 4.0-8.5 between 27 PPMS and 38 SPMS were included in the study. The ratio of female to male was 1,6 / 1.As a result, it has been found in this study that from, in group PPMS patients and SPMS patinets having close EDSS scores, the PPMS patients have much better upper extremity fine motor skills and walking ability, though not statistically, but relatively.en_US
dc.languageTurkish
dc.language.isotr
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 United Statestr_TR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectNörolojitr_TR
dc.subjectNeurologyen_US
dc.titlePrimer ve sekonder progresif multipl skleroz hastalarında üst ekstremite ve alt ekstremite fonksiyonlarının karşılaştırılması
dc.title.alternativeComparison of upper extremity and lower extremity functions in primary and secondary progressed multiple skelerosis patients
dc.typedoctoralThesis
dc.date.updated2018-12-20
dc.contributor.departmentNöroloji Anabilim Dalı
dc.subject.ytmScales
dc.subject.ytmMotor skills
dc.subject.ytmMultiple sclerosis
dc.subject.ytmUpper extremity
dc.subject.ytmLower extremity
dc.subject.ytmExtremities
dc.subject.ytmCentral nervous system
dc.subject.ytmNeurodegenerative diseases
dc.identifier.yokid10186307
dc.publisher.instituteTıp Fakültesi
dc.publisher.universityVAN YÜZÜNCÜ YIL ÜNİVERSİTESİ
dc.type.submedicineThesis
dc.identifier.thesisid503592
dc.description.pages91
dc.publisher.disciplineDiğer


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