Oto immun büllöz hastalıklarda (Pemfigus ve Pemfigoid`de) immunfloresan yönteminin uygulanabilirliği

Abstract

The sera of peraphigius patients contain antibodies to the intercellular ground substance the presence of these antibodies support thfe view of peraphigius is an autoimmune disease. The titers of these antibodies rise during exacerbations and decrease during remissions. Almost all of these antibodies are IgG and bind to the intercellular ground substance in the Malpighi layer. Antibodies isolated during active disease can fix the complement, IgG and/or C, detection by immunofluorescence in the epidermis is diagnostic. In the bullous pemphigius, linear accumulation of C, and/or IgG in the basal membrane is observed, For definite dio gnosis, the deposition of IgG on the epidermal side should be confirmed by indirect split-skin technique.