Show simple item record

dc.contributor.advisorYüksek, Haydar
dc.contributor.authorKurt, İbrahim Halil
dc.date.accessioned2020-12-06T10:02:37Z
dc.date.available2020-12-06T10:02:37Z
dc.date.submitted2013
dc.date.issued2018-08-06
dc.identifier.urihttps://acikbilim.yok.gov.tr/handle/20.500.12812/96957
dc.description.abstractBu çalışmada, öncelikle çalışma için gerekli olan 7 adet 3-alkil(aril)-4-amino-4,5-dihidro-1H-1,2,4-triazol-5-on bileşiği sentezlenmiştir. Sonra bu bileşiklerin 4-hidroksibenzaldehidin trietilamin varlığında fenil asetil klorür ile reaksiyonundan sentezlenen 4-fenilasetoksibenzaldehid ile muamelesinden 7 adet 3-alkil(aril)-4-(4-fenilasetoksibenzilidenamino)-4,5-dihidro-1H-1,2,4-triazol-5-on bileşiği elde edilmiştir.Çalışmanın orjinal bölümünde, 3-alkil(aril)-4-(4-fenilasetoksibenzilidenamino)-4,5-dihidro-1H-1,2,4-triazol-5-on bileşiklerinin asetik anhidrid ile reaksiyonundan 7 adet yeni 1-asetil-3-alkil(aril)-4-(4-fenilasetoksibenzilidenamino)-4,5-dihidro-1H-1,2,4-triazol-5-on bileşiği elde edilmiştir.Çalışmanın ikinci bölümünde sentezlenen 7 yeni bileşiğin yapıları IR, 1H-NMR ve 13C-NMR spektroskopik yöntemleri kullanılarak aydınlatılmıştır. Ayrıca, 7 bileşiğin UV spektrumları alınmış, ?max değerlerine karşın gelen ? değerleri hesaplanmıştır.Daha sonra çalışmada sentezlenen 7 yeni bileşiğin üç farklı yöntemle (indirgeme gücü, serbest radikal giderme aktivitesi ve metal şelat aktivitesi) antioksidan aktiviteleri incelenmiş, grafikleri çizilmiş ve sonuçlar yorumlanmıştır.Anahtar Kelimeler : 4,5-Dihidro-1H-1,2,4-triazol-5-on, Schiff bazı, asetillendirme, antioksidan
dc.description.abstractIn this study, firstly seven 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-one compounds requiring for this study were synthesized. Then, from the reactions of these compounds with 4-phenylacetoxy-benzaldehyde, which was synthesized by the reaction of 4-hydroxybenzaldehyde with phenylacetyl chloride by using triethylamine, were investigated and seven 3-alkyl(aryl)-4-(4-phenylacetoxy-benzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-one compounds were obtained.In the originaly section of the study, 3-alkyl(aryl)-4-(4-phenylacetoxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-one compounds were treated with acetic anhydride and seven novel 1-acetyl-3-alkyl(aryl)-4-(4-phenylacetoxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones were synthesized.In the second part of the study, the structures of seven new compounds were characterized by using IR, 1H-NMR, 13C-NMR spectra. Furthermore, UV spectrums of seven new compounds were investigated and ?max and ? values were calculated.In third part of the study, seven new compounds synthesized were analyzed for their antioxidant activities in three different methods (reducing power, free radical scavenging and metal chelating activity), were drawn their graphs and their results were interpreted.Key Words 4,5-dihydro-1H-1,2,4-triazol-5-one, Schiff Base, acetylation, antioxidanten_US
dc.languageTurkish
dc.language.isotr
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 United Statestr_TR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectKimyatr_TR
dc.subjectChemistryen_US
dc.titleBazı yeni 1,2,4-triazol-5-on türevlerinin sentezi ve in-vitro antioksidan özelliklerinin incelenmesi
dc.title.alternativeSynthesis and studies of in-vitro antioxidant properties of some novel 1,2,4-triazol-5-on derivatives
dc.typemasterThesis
dc.date.updated2018-08-06
dc.contributor.departmentKimya Anabilim Dalı
dc.subject.ytm4,5-dihydro-1H-1,2,4-triazole-5-one
dc.subject.ytmSchiff bases
dc.subject.ytmAntioxidants
dc.subject.ytmAcetylation
dc.identifier.yokid10002733
dc.publisher.instituteFen Bilimleri Enstitüsü
dc.publisher.universityKAFKAS ÜNİVERSİTESİ
dc.identifier.thesisid336921
dc.description.pages123
dc.publisher.disciplineDiğer


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/openAccess
Except where otherwise noted, this item's license is described as info:eu-repo/semantics/openAccess