Labetalol Hidroklorid'in primer ve sekonder hipertansiyon üzerine etkisi

Abstract

- 77 - SUMMARY Labetalol, a a -and B - adrenoceptor blokcing drug, has been used in the treatment of hipertension in a total of kO patients. Heamudynamic effects, clinical pharmacology, plasma lipid effects, side effects, drug interections, and clinical use of labetalol has been reviewed. During the 8 weeks adose of 200-U0Ü mg labetalol daily produced a statistically significant reduction at the systolic blood pressure, both at sitting and supine position. Heart failure and non-speaific side effects uas the reason for stopping treatment in three patientB. No orthostatic hypotension has been observed. It can be concluded that labetalol is an effective and safe drug in the menagement of mild hypertension especielly in cases where beta blocking agents are patentially hazardous.