4-etoksi karbonil-5-fenil-1-(4-(triflorometil)fenil)-1h-pirazol-3-karboksilik asidin sentezlenmesi ve ileri kademe reaksiyonların incelenmesi

Abstract

Bu çalışmada 4-etoksi karbonil-5-fenil- 2,3-furandionların hidrazin ve hidrazonlarla reaksiyonları sonucunda pirazol-3-karboksilli asit türevleri sentezlenmiş ve ileri kademe reaksiyonları incelenmiştir. Sonuç olarak sırasıyla 4-etoksi karbonil-5-fenil-1-(4-(triflorometil)fenil)-1H-pirazol-3-karboksilik asit (AÇ-1), 4-etoksi karbonil-5-fenil-1-(4-(triflorometil)fenil)-1H-pirazol-3-karbonilklorür (AÇ-2), 4-etoksi karbonil-5-fenil-1-(4-(triflorometil)fenil)-1H-pirazol-3-karboksiamid (AÇ-3), (1-(4-(triflorometil)fenil)-5-fenil-1H-pirazol-4-il)(etil)metan-on (AÇ-4), 4-Etoksi karbonil-5-fenil-1-(4-(triflorometil)fenil)-1H-pirazol-3-karboksilikasit propilesteri (AÇ-5), 4-etoksikarbonil-1-(4-(triflorometil)fenil)-5-fenil-1H-pirazol-3-karboksi naftilamid (AÇ-6), 4-etoksikarbonil-1-(4-(triflorometil)fenil)-5-fenil-1H-pirazol-3-karboksi fenil amid (AÇ-7), 4-etoksikarbonil-5-fenil-1-(4-triflorometil)fenil)-1H-3-karbonil)-üre (AÇ-8), heterosiklik bileşiklerinin izolesi gerçekleştirildi. Bu bileşiklerin yapıları elementel analiz, IR, 13C-NMR, 1H-NMR ve 19F-NMR spektrumları ile aydınlatıldı.Anahtar Sözcükler: 4-etoksi-5-fenil-2,3-furandionun, pirazol, piridazin, nükleofil

In this study, 4-etoxy-5-phenyl-2,3-furandion as a result of the reaction hydrazine and hydrazone pyrazole 3-carboxcilic acid derivatives were synthesized and investigated the reaction. As a result, isolation of heterocyclic compounds of 4-etoxy carbonyl-5-phenyl-1-(4-trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylic acid (AÇ-1), 4-etoxy carbonyl-5-phenyl-1-(4-(trifluoromethyl)pheny)-1H-pyrazole-3-carbonyl chloride (AÇ-2), 4-etoxy carbonyl-5-phenyl-1-(4-(trifluoromethyl)pheny)-1H-pyrazole-3-carboxamide (AÇ-3), 1-(4-(trifluoromethyl)pheny)-5-pheny-lH-pyrazole-4-il)(ethyl)methannone (AÇ-4), 4-etoxy carbonyl -5-phenyl-1-(4-(trifluoromethyl)phenyl)1H-pyrazole-3,4-dicarboxylate (AÇ-5), propyl 4-etoxy carbonyl -5-phenyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate (AÇ-6), ), 4-etoxy carbonyl-5-phenyl-1-(4-(trifluoromethyl)pheny)-1H-pyrazole-3-carboxy phenylamide (AÇ-7) , 1-( 4-etoxy carbonyl -5-phenyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonyl)-3-urea (AÇ-8) were taken placed. The structure of these compounds were revealed by elemental analysis, IR, 13C-NMR ve 1H-NMR spectrums.Key Words: 4-benzoyl-5-phenyl-2,3-furandion, pyrazole, pyridazine, nucleophilic addition