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dc.contributor.advisorÇolak, Ahmet
dc.contributor.authorYelkovan, İzzet
dc.date.accessioned2021-05-07T08:59:28Z
dc.date.available2021-05-07T08:59:28Z
dc.date.submitted1989
dc.date.issued2018-08-06
dc.identifier.urihttps://acikbilim.yok.gov.tr/handle/20.500.12812/601939
dc.description.abstract32 VI. ÖZET Bu araştırmada, 2,4-Diklorofenoksiasetik asit (2,4-D)'nin fare karaciğeri Glukoz-6-Fosfat Dehidro- genaz (G-6-P DH) enzim aktivitesi üzerine in vivo et kisi incelenmiştir. İntraperitonal (i.p.) olarak yapılan 2,4-D en feksiyonunda LD50 ve LD30 değerleri sırasıyla 475 ve 338 mg/kg vücut ağırlığı olarak bulunmuştur. 2,4-D`nin O ve 64 saat peryodlarında fare kara ciğeri G-6-P DH enzimi özgül aktivitesini % 1,3 ve % 1,6 oranında inhibe ettiği bulunmuşsa da, istatis tiksel olarak önemli olmadığı (p > 0,05) 2, 4, 8 ve 16 saat peryodlarında ise sırasıyla, % 34.0, % 38,0, % 12,5 ve % 14, 9 oranında inhibe ve 32 saat peryodun da % 4,0 oranında aktive ettiği ve sonuçların ista tistiksel olarak önemli olduğu belirlenmiştir (p<0,05),
dc.description.abstract33 VII. SUMMARY Investigation on the effect of 2,4-D (2,4-Dichloroph.enoxyacetic acid) on the mouse liver G-6-P DH (Glucose -6 -Phosphate Dehydrogenase) enzyme activity. In this research, the in vivo effect of 2,4-Di- chlorophenoxy acetic acid (2,4-D) on the mouse liver Glucose-6-Phosphate Dehydrogenase (G-6-P DH) activity has been investigated. Upon intraperitoneal (i.p.) injection of 2,4-D LDcq and LD,Q values have `been determined to he 475 and 338 mg/kg body weight, respectively. Although it was found that 2,4-D inhibited the mouse liver G-6-P DH enzyme specific activity by 1,3 % and 1,6 % at hour 0 and hour 64, respectively, this considered to be insignificant statistically (p > 0,05). On the other hand, an inhibition of 34,0 %, 38,0 %, 12,5 % and 14,9 % at hours 2, 4, 8 and 16, re spectively, and an activation of 4,0 % at hour 32 were determined and these results were considered to be sig nificant statistically (p < 0,05).en_US
dc.languageTurkish
dc.language.isotr
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 United Statestr_TR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEczacılık ve Farmakolojitr_TR
dc.subjectPharmacy and Pharmacologyen_US
dc.title2,4-D (2,4-Diklorofenoksiasetik asit)`nin fare karaciğerindeki G-6-P DH (glukoz-6 fosfat dehidrogenaz) enzim aktivitesi üzerine etkisinin araştırılması
dc.title.alternativeInvestigation on the effect of 2,4-D (2,4-dichlorophenoxyacetic acid) on the mouse liver G-6-P DH (plucose-6-phosphate dehydropenase) enzyme activity
dc.typemasterThesis
dc.date.updated2018-08-06
dc.contributor.departmentTıbbi Biyoloji ve Genetik Ana Bilim Dalı
dc.subject.ytmMice
dc.subject.ytmHerbicides
dc.subject.ytmLiver
dc.subject.ytm2,4-dichlorophenoxyacetic acid
dc.subject.ytmGlucosephosphate dehydrogenases
dc.identifier.yokid11315
dc.publisher.instituteSağlık Bilimleri Enstitüsü
dc.publisher.universityCUMHURİYET ÜNİVERSİTESİ
dc.identifier.thesisid11315
dc.description.pages47
dc.publisher.disciplineDiğer


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