Torakal ve abdominal aort anevrizmalarında arteryal stifnes incelemesi
dc.contributor.advisor | Durmuş, İsmet | |
dc.contributor.author | Kazaz, Zeynep | |
dc.date.accessioned | 2020-12-29T14:10:49Z | |
dc.date.available | 2020-12-29T14:10:49Z | |
dc.date.submitted | 2010 | |
dc.date.issued | 2018-08-06 | |
dc.identifier.uri | https://acikbilim.yok.gov.tr/handle/20.500.12812/439622 | |
dc.description.abstract | Amaç: Torakal ve abdominal aort anevrizması olan hastalarda arteryal stifness artışı araştırılarak ikisi arasındaki etyopatogenetik ilişkiyi incelemek.Yöntem: Çalışmaya torakal aort anevrizması olan 20 hasta (7 kadın, 13 erkek, ortalama yaş 65 ± 7 yıl), abdominal aort anevrizması olan 18 hasta (7 kadın, 11 erkek, ortalama yaş 69 ± 4 yıl) ve anevrizması olmayan 20 hasta (7 kadın, 13 erkek, ortalama yaş 66 ± 6 yıl) dahil edildi. Tüm hastalara SphygmoCor cihazıyla non-invaziv olarak arteryel stifnes ölçümü yapıldı. Karotis-femoral nabız dalga hızı (karotis-femoral PWV), augmentasyon basıncı (AP) ve kalp hızına normalize edilmiş augmentasyon indeksi (AIx@75) arteryel stifnes parametreleri olarak kullanıldı.Bulgular: Demografik özellikler, lipit paneli ve medikasyon açısından (beta-bloker ve ADE inhibitörü hariç) her üç grup arasında fark yoktu. AP, abdominal grupta torakal gruba göre anlamlı olarak yüksek bulunurken (p= 0.028), AIx@75 abdominal grupta hem torakal hemde kontrol grubuna göre anlamlı olarak yüksek bulundu ( sırasıyla p=0.019, p=0.008). Karotis-femoral PWV abdominal grupta kontrol grubuna göre anlamlı olarak yüksek bulundu (p= 0.002).Sonuç: Abdominal aort anevrizması olan hastalarda arteryal stifnes artışı olurken, torakal aort anevrizmalarında artış saptanmadı. Bu durum abdominal anevrizmanın lokal bir hastalık olmakdan çok sistemik bir patoloji olduğunu ve etyolojide ateroskleroz gibi sistemik bir sebebin rol aldığını düşündürür.Anahtar kelimeler : arteryal stifnes, aort anevrizmaları, pulse wave velosite | |
dc.description.abstract | Aim: To research arterial stiffness increase in patients with thoracal and abdominal aortic aneurysms and to investigate the etiopathogenic relationship between aortic aneurysms and arterial stiffness.Method: Study population included 20 patients with thoracal aortic aneurysm (13 male, 7 female, mean aged 65 ± 7 years), 18 patients with abdominal aortic aneurysms (11 male, 7 female, mean aged 69 ± 4 years), and 20 patiens who had no aortic aneurysm (13 male, 7 female, mean aged 66 ± 6 years). Arterial stiffness measurement was performed in all patients by non-invasive SphygmoCor device. Carotid-femoral pulse wave velocity (PWV), augmentation pressure (AP), and augmentation index normalized for heart rate of 75 bpm (AIx@75) were used as arterial stiffness parameters.Findings: There was no difference among the three groups in terms of demographic characteristics, parameters of lipid status, and medications (except for using beta-blocker and ADE inh.). While AP was found to be significantly higher (p= 0,028) in abdominal aortic aneurysms group compared with thoracal aortic aneurysm group, AIx@75 was found to be significantly higher in abdominal aortic aneurysms group compared with both thoracal aortic aneurysm group and control group (p=0.019 and p=0.008 respectively). Carotid-femoral PWV was found to be significantly higher (p= 0.002) in abdominal aortic aneurysm group compared with control group.Conclusion: While arterial stiffness increased in patient with abdominal aortic aneurysms, it did not increase in patients with thoracal aortic aneurysm. This condition suggests that abdominal aortic aneurysms is a systemic pathology rather than a local disease and its etiology consists of a systemic cause such as atherosklerozis.Keywords : arterial stiffness, aortic aneurysms, pulse wave velocity | en_US |
dc.language | Turkish | |
dc.language.iso | tr | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | Attribution 4.0 United States | tr_TR |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Kardiyoloji | tr_TR |
dc.subject | Cardiology | en_US |
dc.title | Torakal ve abdominal aort anevrizmalarında arteryal stifnes incelemesi | |
dc.title.alternative | Investigation of arterial stiffness in thoracic and abdominal aortic aneurysms | |
dc.type | doctoralThesis | |
dc.date.updated | 2018-08-06 | |
dc.contributor.department | Kardiyoloji Anabilim Dalı | |
dc.subject.ytm | Aortic aneurysm | |
dc.subject.ytm | Aorta | |
dc.subject.ytm | Aorta-abdominal | |
dc.subject.ytm | Aorta-thoracic | |
dc.subject.ytm | Heart rate | |
dc.subject.ytm | Atherosclerosis | |
dc.subject.ytm | Arteries | |
dc.identifier.yokid | 390111 | |
dc.publisher.institute | Tıp Fakültesi | |
dc.publisher.university | KARADENİZ TEKNİK ÜNİVERSİTESİ | |
dc.type.sub | medicineThesis | |
dc.identifier.thesisid | 267889 | |
dc.description.pages | 68 | |
dc.publisher.discipline | Diğer |