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dc.contributor.advisorDeğer, Orhan
dc.contributor.authorKirci, Dursun
dc.date.accessioned2020-12-29T14:10:08Z
dc.date.available2020-12-29T14:10:08Z
dc.date.submitted1991
dc.date.issued2018-08-06
dc.identifier.urihttps://acikbilim.yok.gov.tr/handle/20.500.12812/439507
dc.description.abstractÖZET EDTA'lı plazma numunelerinde PMN elastaz- ot. -^-proteinaz inhibitörü (E-^-PI) düzeyleri iki farklı metodla (ELISA ve IMAC) tayin edildi. Her iki metodun hassasiyeti ve doğruluğu birbirine yakın bulundu. E-E1-PI miktarı oda sıcaklığında 6 saat, derin dondurucuda (-20 °C) 1 ay süreyle stabil kaldı. Akut romatoid artrit ve üveitli hastalarda ortalama E-e1-PI düzeyleri kontrol grubundan önemli derecede yüksekti. PMN Elastaz' m inflamatuar hastalıklarda, hastalık aktivitesinin tayininde ve tedavinin izlenmesinde önemli bir markör olabileceği kanaatine varıldı. Anahtar Kelimeler : PMN Elastaz, polimorfonükleer lökositler, inf lamasyon, enzyme-linked immunosorbent assay (ELISA), immunoaktivasyon (IMAC), romatoid artrit, üveit.
dc.description.abstractSUMMARY In blood plasma samples (with EDTA), PMN elastase- <*¦]_- proteinase inhibitor (E-e^-PI) levels were determined by two different methods (ELISA and IMAC). Precision and accuracy of the both methods were similar. E-^-PI level was remained unchanged for 6 hours in room temperature and 1 month in deep-freeze (-20 °C). The mean E-«<^-PI levels of patients with romatoid arthritis and uveitis were significantly higher than that of normal subjects. It was concluded that PMN Elastase may be an important marker in determination of disease activity and in follow- up- of the treatment in inflamatuar diseases. Key Words : PMN Elastase, polimorphonuclear leukocytes, inflammation, enzyme-linked immunosorbent assay (ELISA), immunoactivation analysis (IMAC), rheumotoid arthritis, uveitis.en_US
dc.languageTurkish
dc.language.isotr
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.rightsAttribution 4.0 United Statestr_TR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBiyokimyatr_TR
dc.subjectBiochemistryen_US
dc.titlePMN elastazın inflamatuar hastalıklarda markör özelliğinin ve tayin şartlarının incelenmesi
dc.typemasterThesis
dc.date.updated2018-08-06
dc.contributor.departmentBiyokimya Anabilim Dalı
dc.subject.ytmInflammation
dc.subject.ytmElastase
dc.subject.ytmPolymorphism-genetic
dc.identifier.yokid12153
dc.publisher.instituteSağlık Bilimleri Enstitüsü
dc.publisher.universityKARADENİZ TEKNİK ÜNİVERSİTESİ
dc.identifier.thesisid12153
dc.description.pages48
dc.publisher.disciplineDiğer


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