Diyette margarin kullanımının bazı plazma ve eritrosit membran lipidleri üzerine olan etkisinin incelenmesi

Abstract

49 ÖZET Margarinli ve margarinsiz diyet alımının plazma lipidleri, lipoproteinleri, membran kolesterolleri ile yağ asitleri üzerine olan etkileri; 30 margarin kullanan ve 30 margarin kullanmayan şahıslar arasında karşılaştırıldı. Margarin kullanan şahısların, plazma kolesterol değeri ortalama 200.90+21.08 mg/dL, LDL kolesterolü 124.54+13.34 mg/dL, HDL kolesterolü 48.80+15.26 mg/dL, trigliserid değeri 133.73 +28.65 mg/dL, eritrosit membran değeri 1.29 +0.07 mg/10 10 hücre olarak tesbit edildi Margarinli diyet alanların eritrosit membranlanndan, pentanoik asit, heptanoik asit, nonanoik asit, trideakanoik asit, oleik asit, erukik asit, petroselinik asit yağ asitleri elde edildi. Margarin alan şahısların plazma kolesterolleri ile LDL kolesterol(r=0.39, p<0.05), HDL kolesterol (r=.064, p<0.05)ve trigliserid (r=0.47 p<0.05) değerleri arasmda anlamh bir ilişkiye rastlanmıştır. Fakat eritrosit membran kolesterolü ile diğer lipid değerleri arasmda anlamlı bir ilişki gözlenmemiştir. Margarinsiz diyet alan şahısların plazma kolesterolü ortalama 182.56+26.70 mg/dL, LDL kolesterolü 104.37+18.04 mg/dL, HDL kolesterolü 56.73+9.85 mg/dL, trigliserid değeri 102.37+45.78 mg/dl, eritrosit membran değeri 1. 17+0.09 mg/1010 hücre olarak tesbit edildi. Margarin kullanmayanların eritrosit memranlanndan, pentanoik asit, heptanoik asit, nonanoik asit, tridekanoik asit, pentadekanoik asit, heptadekanoik asit, stearik asit, oleik asit, linoleik asit, heneikosanoik asit, erukik asit yağ asitleri elde edildi. Margarinsiz diyet kullananların plazma kolesterolleri ile LDL kolesterol ( r=0.87, pO.001), HDL kolesterol(r=.37, p<0.05), ve trigliserid (r=0.42, p<0.05) değerleri arasmda anlamh bir ilişkiye rastlanmıştır. Fakat eritrosit membran kolesterolü ile diğer lipid değerleri arasında anlamh bir ilişki gözlenmemiştir.50 Margarin kullanan ve kullanmayan şahısların plazma kolesterolleri, LDL ve HDL kolesterolleri, trigliserid değerleri, eritrosit membran kolesterol değerleri arasında anlamlı bir fark tesbit edilmiştir. Margarin kullanan şahıslarda plazma lipid, lipoprotein ve eritrosit membran kolesterol değerlerinin artması, margarinsiz diyet alanlarda azalması; satüre, monoansatüre, poliansatüre diyetlerin plazma lipid değerlerini etkileyebileceğini ve plazma ile membran arasında bir değişimin olabileceğini düşündürmektedir.

51 SUMMARY The effect of diet aplication with and withhout margarine on plasma lipids,lipoproteins, membrane cholesterol and fatty acids were studied and the study took place between 30 margarine users and 30 non-margarine users. The mean value of plasma cholesterol in the margarine users was determined as 200.90+21.08 mg/dL, LDL cholesterol as 124.54+13.34 mg/dL, HDL cholesterol as 48.80+1 5. 26mg/dL, the value of triglyceride as 133.73 + 28.65 mg/dl, and the value of erythrocyte membrane as 1.29+0.07 mg/10^ cells. Pentanoic acid, heptanoic acid, nonanoic acid, tridecanoic acid, oleic acid, erucic acid, petroselinic acid fatty acids were obtained from erythrocyte membranes of the people with margarine. A considerable relation was found out between the plasma cholesterol of the margarine users and the values of LDL cholesterol, HDL cholesterol and triglyceride. But no considerable relation was observed between the values of erythrocyte cholesterol and other lipid values. The mean plasma cholesterol in the people with non-margarine diet was determined as 182.56+ 26. 70mg/dL, LDL cholesterol as 104.37+ 18.04mgdL, HDL cholesterol as 56.73+9.85 mg/dL, the value of triglyceride as 102.37 ± 45.78 mg/dL, the value of erythrocyte membrane as 1.17+0.09 mg/1010 cells. Pentanoic acid, heptanoic acid, nonanoic acid, tridecanoic acid, pentadecanoic acid, heptadecanoic acid, oleic acid, linoleic acid, heneicosanoic acid, erucic acid, fatty acids were obtained from erythrocyte membranes of the non-margarine users. A meaningful relation was found out between the plasma cholesterol of the people with no margarine diyet and LDL cholesterol, HDL cholesterol and the value of triglyceride. But no meaningful relation was observed between erythrocyte cholesterol values and other lipid values.52 A meaningful relation was found out between the plasma cholesterol of the people with no margarine diyet and LDL cholesterol, HDL cholesterol and the value of triglyceride. But no meaningful relation was observed between erythrocyte cholesterol values and other lipid values. A meaningful difference among the plasma cholesterol, LDL cholesterol, HDL cholesterol, the value of triglyceride and the value of erythrocyte margarine users and non- margarine was found out. The fact that the values of plasma lipids and, lipoprotein and erythrocyte membrane cholesterol increased in the margarine-using people and that the same values decreased in the people with no margarine diet showed that saturated, monounsaturated and poliunsaturated diets may effect the plasma lipid values and that a change between plasma and membrane may occur.