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dc.contributor.advisorYavuz, Turhan
dc.contributor.authorTenekeci, Cumhur
dc.date.accessioned2020-12-10T12:01:06Z
dc.date.available2020-12-10T12:01:06Z
dc.date.submitted2005
dc.date.issued2018-08-06
dc.identifier.urihttps://acikbilim.yok.gov.tr/handle/20.500.12812/274753
dc.description.abstract32 ÖZET Nitrogliserinin Koroner Endotel Hasarı Üzerine Etkisi Çalışan kalpte bypass cerrahisi tüm popülaritesine rağmen koroner arter üzerine uygulanan üflemenin endotele zararlı etkisi nedeniyle özellikle dikkat istemektedir. Nitrogiserin ise vazoaktif özelliği iyi bilinen bir ilaçtır. Çalışmamızda ratları iki guruba ayırıp asenden aortalarına bir gruba serum fizyolojikli yıkama diğer gruba ise nitrogliserinli yıkama tatbik ettik. Histopatolojik incelemede kontrol grubunun aortalarında tip 3, çalışma grubunda ise tip 2 endotel hasarı vardı. Sonuçta vazoaktif etkili ilaç ilaveli koroner yıkamanın endotel hasarını tümüyle önlemese de, hasarın şiddetini azalttığı kanısına vardık.
dc.description.abstractSUMMARY The Effect of Nitroglycerine on Coronary Endothelial Damage Coronary artery by pass grafting on the beating heart especially takes attention because of the negative effect of insufflation on the coronary endothelial in spite of its popularity. Nitroglycerine is a well known drug that has vasoactive property. In our study we divided the rats in to two groups and we applied insufflation with serum physiologic to first group, insufflation with nitroglycerine to second group into their ascenden aortas. In histopathological studies there was type 3 endothelial damage in the control group, type 2 endothelial damage in the study group. Finally we decided that coronary insufflation with vasoactive drug reduces the severity of damage although it can not completely prevent the endothelial damage.en_US
dc.languageTurkish
dc.language.isotr
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.rightsAttribution 4.0 United Statestr_TR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGöğüs Kalp ve Damar Cerrahisitr_TR
dc.subjectThoracic and Cardiovascular Surgeryen_US
dc.titleÇalışan kalpte koroner bypass cerrahisinde üfleme sistemine ilave edilen nitrogliserinin endotel hasarına etkisi
dc.title.alternativeThe effect of nitroglycerine on coronary endothelial damage
dc.typedoctoralThesis
dc.date.updated2018-08-06
dc.contributor.departmentKalp ve Damar Cerrahisi Anabilim Dalı
dc.identifier.yokid182976
dc.publisher.instituteTıp Fakültesi
dc.publisher.universitySÜLEYMAN DEMİREL ÜNİVERSİTESİ
dc.type.submedicineThesis
dc.identifier.thesisid163348
dc.description.pages43
dc.publisher.disciplineDiğer


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