Alkole bağlı karaciğer hasarının önlenmesinde sarımsak, vitamin E ve melatonin etkilerinin kıyaslanması

Abstract

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THE COMPARISION OF THE EFFECTS OF GARLIC, VITAMINE E ANDMELATONIN ON THE ALCOHOL DEPENDENT LIVER DAMAGEDr.Serpil FIRATSUMMARYIt is thought that the harmfull effects of alcohol could be prevented byantioxidant treatment. To achieve this aim, it is decided to feed alcoholic rats withgarlic, which is suggested to have antioxidant properties and compare garlic?s effectswith vitamin E and melatonin, whichs? antioxidant properties have been proven.Male Wistar albino rats were used in the experiments. The animals were housedin quiet rooms with diurnal ligt-and dark cycle and were given ethanol (%10,as soledrinking fluid), garlic homogenate (250 mg/kg/d, per oral), melatonin (10 mg/kg/d, subcutaneously) and vitamin E (200 mg/kg, two times a week, per oral) for 6 weeks. Afterthe experimental procedure, the rats were killed by bleeding, the liver was removed andthe oxidant and antioxidant parameters were studied.The data is evaluated according to the statistical rules and the results werecriticized. In relation with these information, when compared with the alcoholic andgarlic groups vitamine E and melatonin caused, a statistically significant decrease in theratio of lipid peroxidation and GSH levels, and a statistically significant increase in GPxenzyme levels when compared with the alcoholic and garlic groups. The increase inGSH levels in the garlic group might come from the organosulphur content of garlic andit is concluded that, garlic?s hepatoprotective effect would be more efficient when thereis a need for the organosulphur compounds and GSH. From that point of view, in orderto prove the exact prophylactic effect of garlic in alcohol users, further studies withlonger experimental procedures are needed to be processed.Key Words: Garlic, vitamin E, melatonin, antioxidative effect