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dc.contributor.advisorSeçkin, Yüksel
dc.contributor.authorDinçer Aydin, Sevcan
dc.date.accessioned2020-12-07T10:41:13Z
dc.date.available2020-12-07T10:41:13Z
dc.date.submitted2017
dc.date.issued2020-08-23
dc.identifier.urihttps://acikbilim.yok.gov.tr/handle/20.500.12812/133500
dc.description.abstractİnönü Üniversitesi Üniversitesi Tıp Fakültesi Gastroenteroloji Polikliniğine başvuran karaciğer sirozlu hastaların epidemiyolojik, laboratuvar ve klinik verilerinin sıklığının araştırılması amaçlandı. Çalışmamıza 510 hasta dahil edildi. Hastalarımızın yaş ortalaması 54,21(± 14,76) idi. Hastalarımızın 327'sini (%64,1) erkek, 183'ünü (%35,9) kadın oluşturmaktadır. Siroz etyolojisi incelendiğinde 227'sinde (%44,5) Hepatit B Virüs (HBV), 60'ında (%11,8) Hepatit C Virüs (HCV), 17'sinde (%3,3) kronik alkol kullanımı, 11'inde (%2,2) Budd Chiari sendromu, 9'unda (%1,8) otoimmun hepatit, 8'inde (%1,6) HBV+HCV, 8'inde (%1,6) Wilson hastalığı, 4'ünde (%0,8) hepatosteatoz, 3'ünde (%0,6) HBV+Hepatit D Virüs (HDV), 3'ünde (%0,6) primer biliyer siroz (PBS), 2'sinde (%0,4) hemakromatozis, 1'inde (%0,2) primer sklerozan kolanjit (PSK), 1'inde (%0,2) Gaucher hastalığı, 1'inde (%0,2) alfa-1 antitripsin eksikliği tespit edildi. 155 hastada (%30,4) etyoloji bulunamadı ve bu hastalar kriptojenik karaciğer sirozu olarak kabul edildi. Klinik verilerde hastaların 384'ünde (%75,3) dekompanse siroz, 126'sında (%24,7) kompanse siroz mevcuttu. Komplikasyonlar araştırıldığında 302'sinde (%59,2) asit tespit edildi, 152'si (%29,8) bilinmemekle birlikte, 98'inde (%19,2) grade 1, 84'ünde (%16,5) grade 2, 61 'inde (%12) grade 3 özofagus varis gözlendi. 42'sinde (%8,2) portal ven trombozu, 29'unda (%5,7) özofagus varis kanaması, 27'sinde (%5,3) hepatik ensefalopati, 9'unda (%1.8) spontan bakteriyel enfeksiyon, 6'sında (%1,2) hepatorenal sendrom tespit edildi. Hastaların 97'sinde (%19) hepatosellüler karsinom (HCC) tespit edildi. 510 hastanın 165'ine (%32,3) antiviral tedavi, 1'ine (%0,2) enzim tedavisi, 6'sına (%1,2) immunsupresif tedavi başlandı. 338'si (%66,3) tedavisiz izlendi. 170'ine (%33,3) karaciğer transplantasyonu yapıldı. Sonuç olarak karaciğer sirozda etyolojide en sık neden viral etkenler saptandı. Viral etkenden de HBV'nin en sık neden olduğu görüldü. Hastaların %30,4'ünde ise etyolojik neden saptanmadı.
dc.description.abstract510 patients diagnosed with liver cirrhosis who were referred to İnönü University Turgut Özal Medical Center gastroenterology polyclinic were studied and the frequency of epidemiological, laboratory and clinical data of liver cirrhosis was aimed in our study. The ages of our patients ranged from 18 to 86 years and the mean age was 54,21 (± 14.76). 327 (64,1%) of the patients were male and 183 (35,9%) were female. When analyzed in liver cirrhosis etiology 227 (44,5%) Hepatitis B Virus (HBV), 60 (11,8%) hepatitis C virus (HCV), 17 (3,3%) chronic alcohol use, 11 (2,2%)Budd's Chiari syndrome, 9 (1,8%) otoimmun hepatitis, 8 (1,6%) HBV+HCV, 8 (1,6%) Wilson's disease, 4 (0,8%) hepatosteatosis, 3 (0,6%) HBV + Hepatitis D Virus (HDV), 3 (0,6%) primary biliary cirrhosis (PBS), 2 (0,4%) hemokromatozis, 1 (0,2%) primary sclerosing cholangitis (PSK) , 1 (0,2%) Gaucher disease and 1 (0,2%) alpha-1 antitrypsin deficiency were determined. No etiological cause was found in 155 patients (30,4%), and these patients were identified as cryptogenic liver cirrhosis. In clinical trials, 384 patients (75,3%) had decompensated cirrhosis and 126 patients (24,7%) had compensated cirrhosis. When we examined the complications of liver cirrhozis, it appeared that there were ascites in 302 (59,2%) patients, furthermore we observed that there were grade 1 esophageal varices in 98 (19,2%) patients, grade 2 in 84 (16,5%) patients and grade 3 in 61 (12%) patients. We hadn't known esophageal varices grade in 152 (29,8%) patients. Portal vein thrombosis in 42 (8,2%), esophageal variceal bleeding in 29 (5,7%), hepatic encephalopathy in 27 (5,3%), spontaneous bacterial infection in 9 (1,8%), hepatorenal syndrome in 6 (1,2%) was detected. Hepatocellular carcinoma (HCC) was detected in 97 patients (19%). Antiviral therapy was given to 165 (32,3%), enzyme therapy to 1 (0,2%) and immunsupressive therapy to 6 (1,2%) of the 510 patients. 338 (66,3%) were follewed without treatment. Liver transplantation was performed in 170 patients (33,3%). No etiologic cause was found in 30,4% of the patients.In conclusion, viral factors were the most common cause of etiology in liver cirrhosis. HBV was the most common cause of the viral factors.en_US
dc.languageTurkish
dc.language.isotr
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 United Statestr_TR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGastroenterolojitr_TR
dc.subjectGastroenterologyen_US
dc.title2010-2016 yılları arasında İnönü Üniversitesi Tıp fakültesine başvuran karaciğer sirozlu hastaların epidemiyolojik, laboratuvar ve klinik verilerinin araştırılması
dc.title.alternativeInvestigation of epidemiological, laboratory and clinical particulars of liver cirrhosis patients who apply to the Medical faculty of İnonu University between 2010-2016
dc.typedoctoralThesis
dc.date.updated2020-08-23
dc.contributor.departmentİç Hastalıkları Anabilim Dalı
dc.subject.ytmMalatya
dc.subject.ytmLiver diseases
dc.subject.ytmLiver cirrhosis
dc.subject.ytmEpidemiology
dc.subject.ytmEtiology
dc.subject.ytmTreatment
dc.subject.ytmComplications
dc.identifier.yokid10162001
dc.publisher.instituteTıp Fakültesi
dc.publisher.universityİNÖNÜ ÜNİVERSİTESİ
dc.type.submedicineThesis
dc.identifier.thesisid466876
dc.description.pages61
dc.publisher.disciplineDiğer


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