Bazı tiyofen-2-karboksilik asit türevi 1,3,4-tiyadiazol bileşiklerinin sentezi, karakterizasyonu ve antifungal aktivitelerinin belirlenmesi

Abstract

Bu tezçalışmasında 2-Tiyofen karboksilik asit ile N-fenil tiyosemikarbazit türevlerinin fosfor oksiklorür katalizörlüğündeki reaksiyonundan, 5-(2-tienil)-N-fenil-1,3,4-tiyadiazol (1), 5-(2-tienil)-N-[3'-klorofenil]-1,3,4-tiyadiazol (2), 5-(2-tienil)-N-[4'-klorofenil]-1,3,4-tiyadiazol (3), 5-(2-tienil)-N-[2'-florofenil]-1,3,4-tiyadiazol (4), 5-(2-tienil)-N-[4'-florofenil]-1,3,4-tiyadiazol (5), 5-(2-tienil)-N-[4'-nitrofenil]-1,3,4-tiyadiazol (6), 5-(2-tienil)-N-benzil-1,3,4-tiyadiazol (7), 5-(2-tienil)-N-[2'-metoksifenil]-1,3,4-tiyadiazol (8), 5-(2-tienil)-N-[3'-metoksifenil]-1,3,4-tiyadiazol (9), 5-(2-thienyl)-N-[4'-metoksifenil]-1,3,4-tiyadiazol (10) bileşikleri sentezlendi. Sentezlenen bu bileşikler elementel analiz ve FT-IR, H-NMR, C-NMR temel yöntemleriyle karakterize edildi. Yeni sentezlenen bu bileşiklerin antimikrobiyal aktiviteleri disk difüzyon deneyi ile incelendi. Bazı bileşiklerin deney mikroorganizmalarına karşı orta derecede aktiviteleri tespit edildi.

In this thesis, we synthesized to 5-(2-thienyl)-N-phenyl-1,3,4-thiadiazole (1), 5-(2-thienyl)-N-[3'-chlorophenyl]-1,3,4-thiadiazole (2), 5-(2-thienyl)-N-[4'-chlorophenyl]-1,3,4-thiadiazole (3), 5-(2-thienyl)-N-[2'-fluorophenyl]-1,3,4-thiadiazole (4), 5-(2-thienyl)-N-[4'-fluorophenyl]-1,3,4-thiadiazole(5), 5-(2-thienyl)-N-[4'-nitrophenyl]-1,3,4-thiadiazole (6), 5-(2-thienyl)-N-benzyl-1,3,4-thiadiazole (7), 5-(2-thienyl)-N-[2'-methoxyhenyl]-1,3,4-thiadiazole (8), 5-(2-thienyl)-N-[3'-methoxyhenyl]-1,3,4-thiadiazole (9), 5-(2-thienyl)-N-[4'-ethoxyhenyl]-1,3,4-thiadiazole (10) compounds by the reaction of 2-Thiophenecarboxylic acid and N-phenyl thiosemicarbazide in the presence of phosphorous oxychloride. The compounds 1-10 characterized with elemental analysis, FT-IR, 1H-NMR and13C-NMR techniques. The compounds were investigated for their antimicrobial activities with disk diffusion method. Some of compounds were found to have moderate activities against test microorganisms.